HIGHLY EFFICIENT CLINICAL TRIALS SIMULATOR (HECT): SOFTWARE APPLICATION FOR PLANNING AND SIMULATING PLATFORM ADAPTIVE TRIALS [VERSION 2; PEER REVIEW: 1 APPROVED, 2 APPROVED WITH RESERVATIONS]

Background: Adaptive designs and platform designs are among two common clinical trial innovations that are increasingly being used to manage medical intervention portfolios and attain Hair faster regulatory approvals.Planning of adaptive and platform trials necessitate simulations to understand how a set of adaptation rules will likely affect the p

In this contribution we studied the trophic ecology of four Characidae species from the Cavalo Stream, upper Tocantins River, considering diet overlap and trophic niche breadth.The diet of the four species was composed of CLO LIGHTLY LEM adult and immature insects, both autochthonous and allochthonous in origin.Autochthonous items dominated the die

Aliarcobacter butzleri is a Gram-negative bacterium associated with infections of the gastrointestinal tract and widely distributed in various environments.For successful infection, A.butzleri should be able to tolerate various stresses during gastrointestinal passage, such as bile.Bile represents an antimicrobial host barrier that acts against ext

One of the greatest archaeological enigmas is in understanding the role of decision-making, intentionality and interventions in plant life cycles Structural Material by foraging peoples in transitions to and from low-level food production practices.We bring together archaeological, palaeoclimatological and botanical data to explore relationships ov

In this essay, we analyze how different actors contribute to compliance with the advisory jurisdiction of the Inter-American human rights system.The essay briefly reviews the discussion around the binding force of, and compliance Moisturizer with, advisory opinions.It then analyzes how the holdings in advisory opinions issued by the Inter-American